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What Is Mitragynine and Why Does It Matter?

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What Is Mitragynine and Why Does It Matter? - Official Dollar Tabs

Before 7OH dominated the conversation, kratom was mitragynine – and for good reason. It is the alkaloid the plant produces most of, and the one most published kratom research focuses on.

What mitragynine is

Mitragynine is the dominant alkaloid in Mitragyna speciosa, the kratom tree. It accounts for roughly 60% of the plant’s total alkaloid content and typically represents around 1% to 1.5% of dried leaf weight. That abundance is what makes it central: it is the compound you get meaningful quantities of simply from the leaf.

How it compares to 7OH

 Mitragynine7-OH
Abundance in leafRoughly 1-1.5% of dried weightWell under 0.1%
Potency by weightLowerConsiderably higher
Typical milligram rangeTens to low hundreds of mgLow single digits to tens of mg
Our productsTablets, powders, drink mixTablets, shots, powder

The practical point: a 50mg MIT tablet and a 50mg 7OH tablet share a number on the label and nothing else. See the full comparison.

Why it often makes a better starting point

Because it is the alkaloid present in the plant in meaningful quantity, mitragynine is closer to the traditional leaf experience than concentrated 7OH. If you are new to kratom alkaloids as a category, starting with mitragynine means starting at a lower relative potency with a wider margin for error.

Our 50mg MIT tablets are pre-dosed in strawberry or lemon – no measuring, no equipment. For something different, the 150mg MIT hot chocolate dissolves into a real cocoa drink.

Formats we sell

What the research does and does not show

Mitragynine has been the subject of considerable laboratory and animal research – more than 7OH, largely because it is the dominant alkaloid. That research is preliminary. Laboratory and animal models are not clinical evidence, and mitragynine has no approved medical use anywhere.

We make no claims about effects. Any vendor telling you what mitragynine does for pain, mood, energy or anything else is going beyond what the evidence supports.

Responsible use

  • One serving per day maximum. Do not exceed the label.
  • 21+ only. Not for use if pregnant, nursing, or taking prescription medication without medical clearance.
  • Never combine with alcohol or other CNS depressants.
  • Do not drive or operate machinery after use.
  • Tolerance builds and dependence is possible – see the dosage guide.
  • Keep out of reach of children and pets.

Related reading

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Pre-dosed tablets, dissolving drink mix and sealed powder bundles.

21+ only. Not for sale to minors. Products sold on this website contain kratom-derived alkaloids. These statements have not been evaluated by the Food and Drug Administration and these products are not intended to diagnose, treat, cure or prevent any disease. Consult a licensed healthcare professional before use and never combine with alcohol or other substances.

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Browse our full range of 7OH tablets, 7OH shots, 7OH powders, mitragynine tablets and bundles. Free shipping on orders over $500 and same-day dispatch before 3PM ET.

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